Interleukin 6 IL 6 is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions buy cialis 10mg One such example is activation of RAGE, a member of the immunoglobulin superfamily of cell surface molecules that recognizes a variety of ligands including HMGB1, S100 proteins, advanced glycation end products, B 2 integrins, amyloid ОІ, and amyloid fibrils but not PAMPs